Hinweis zum Urheberrecht | Allgemeine Informationen | FAQ
Beim Zitieren dieses Dokumentes beziehen Sie sich bitte immer auf folgende URN: urn:nbn:de:hbz:5N-21448

 

Medizinische Fakultät - Jahrgang 2010

Titel Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea
Importance of co-morbidity and serum C-reactive protein
Autor Christian Hardt
Publikationsform Dissertation
Abstract AIM: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.
METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.
RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P <0.001) were independent predictors of severe CDAD.
CONCLUSION: Patients with a severe level of comorbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.
Komplette Version pdf-Dokument (1,5 MB) Hier können Sie den Adobe Acrobat Reader downloaden
© Universitäts- und Landesbibliothek Bonn | Veröffentlicht: 08.12.2010