| Titel | Marine-derived fungi a source for structurally new and bioactive secondary metabolites |
| Autor | Kerstin Neumann |
| Publikationsform | Dissertation |
| Abstract | The marine habitat has been proven to be a rich source for both macro- and microorganisms that produce novel and often highly bioactive natural products. Hence, the investigation of the secondary metabolite spectrum of marine fungi represents a valuable approach in the search for new and bioactive natural products. The present study thus focused on the investigation of marine-derived fungi with the aim to isolate bioactive secondary metabolites via a bioassay-guided isolation strategy. Special emphasis was placed on new structural types and their ability to act as antitumor or, in second priority, antibiotic agents. From the cytotoxicity screening program undertaken within the Institute for Pharmaceutical Biology, five fungal strains with cytotoxic activity towards cancer cells and interesting chemical features, i. e. 1H-NMR and LC-MS data, were chosen for detailed investigation. From these fungal cultures altogether 19 compounds and two peptidic mixtures have been isolated and their structures characterized. more... |
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