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Mathematisch-Naturwissenschaftliche Fakultät - Jahrgang 2008

 

Titel

DNA methylation profiles of cytokine and transcription factor genes in immune cells
applicability as diagnostic biomarkers

Autor

Claudia Ivascu

Publikationsform

Dissertation

Abstract

The past years have seen an enormous scientific interest in the field of DNA methylation. Numerous studies have documented the functional significance of DNA methylation in the regulation of gene expression and the maintenance of local chromatin structure. A large body of evidence underlines the implication of aberrant DNA methylation in nearly all types of human cancers.
The focus of the current work was to investigate the role of DNA methylation in the human immune system at candidate immune-relevant genes by emphasising two key biological aspects.
First, the role of DNA methylation as an epigenetic mark, possessing the function to memorize the expression phenotype, was analyzed within key cytokine genes. Large-scale methylation profiling experiments of these genes were carried out in designated CD4+ memory T-cells subsets. DNA methylation in the IL10 gene, encoding the anti-inflammatory cytokine IL-10 and in the IFNg gene, encoding the pro-inflammatory cytokine IFN-g were of special interest due to the key role of these molecules in the immune response. more...

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© Universitäts- und Landesbibliothek Bonn | Veröffentlicht: 2008